Meet the Team

Rita Z. Goldstein, PhD, Chief

Dr. Goldstein is the Mount Sinai Professor in Neuroimaging and Addiction at the Department of Psychiatry with a secondary appointment at the Department of Neuroscience/Friedman Brain Institute (FBI) in the Icahn School of Medicine at Mount Sinai (ISMMS). Dr. Goldstein directs the Neuroimaging of Addictions and Related Conditions (NARC) Research Program, and previously the Brain Imaging Center (BIC) at ISMMS, both internationally recognized for their use and development of innovative multimodality neuroimaging methods (including MRI, PET, EEG/ERP) for the translational study of brain morphology and function.

Nationally and internationally known for her neuroimaging and neuropsychological studies in drug addiction, Dr. Goldstein formulated a theoretical model known as Impaired Response Inhibition and Salience Attribution (iRISA). Multiple neuroimaging modalities—including MRI, EEG/ERP, PET—and neuropsychological tests are used to explore the neurobiological underpinnings of iRISA in drug addiction and related conditions. This model has drawn considerable scientific attention (exceeding 3,000 citations for a review published in the Am J Psychiatry in 2002 and 2,000 for another review published in Nature Reviews Neuroscience in 2011). An important application of Dr. Goldstein’s research is to facilitate the development of intervention modalities that would improve cognitive and emotional function, leading to better treatment outcomes, in drug addiction and other chronically relapsing disorders of self-regulation.

Dr. Goldstein is a recognized leader in the neuroimaging study of the cognitive and emotional processes underlying human drug addiction. Her research interests include the elucidation of the role of dopamine and prefrontal cortical deficits in iRISA (Impairments in Response Inhibition and Salience Attribution or the compromised ability to change ongoing willed-behavior in response to an emotionally salient feedback) in drug addiction and other disorders of self-control. Dr. Goldstein's interests also include pharmacological fMRI, real-time neurofeedback using Brain Computer Interface, and brain stimulation (e.g., with tDCS). She has also been exploring the contribution of individual differences, including recency of drug use (across both stimulants and opiates), sex differences and polymorphisms in monoaminergic genes, to addiction and aggression, with a focus on the neural mechanisms underlying real-life/naturalistic brain function/behavior, reinforcement learning, risk-taking and extinction, choice and decision-making, and self-awareness and insight into severity of illness. Read more.

Nelly Alia-Klein, PhD, Co-Chief

Dr. Nelly Alia-Klein is an Associate Professor at the Medical School. Dr. Alia-Klein received her PhD in Clinical Psychology from the Graduate School of Arts and Sciences at Columbia University, New York City, in 2002 followed by an internship at Hillside Hospital in adult psychology. She completed a three-year post-doctorate in neuroimaging of addiction at Brookhaven National Laboratory T32 training program. Dr. Alia-Klein’s research interests concentrate on gene-brain-behavior mechanisms underlying violent behaviors and drug addiction. She has both the expertise and clinical experience to conduct innovative and integrated basic and clinical translational research studies that aim to elucidate complex psychopathology.

Eduardo Butelman, PhD, MS

Eduardo is an Assistant Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai. He received his Doctorate in Psychology in Psychology from University College London, followed by training in behavioral pharmacology at the University of Michigan School of Medicine. He then joined the Research Faculty in the Laboratory on the Biology of Addictive Diseases at the Rockefeller University.

Eduardo’s initial work focused on the behavioral, analgesic and respiratory effects of drugs of abuse such as opioids, in preclinical models. He has also worked extensively in peripheral biomarker studies, both in clinical and preclinical studies. More recently he has also characterized major stages in the trajectory of opioid and cocaine use disorders in clinical studies, and their relationship to gender and early adolescent exposure.

Ahmet Ceceli, PhD

Dr. Ceceli is a postdoctoral fellow at NARC. He received his master’s degree in New York University (PI: Dr. Elizabeth Phelps), where he studied the psychophysiological bases of emotional learning. He completed his PhD in psychology, specializing in cognitive neuroscience, at Rutgers University-Newark (PI: Dr. Elizabeth Tricomi), investigating the neurobehavioral mechanisms underlying habits in attention-deficit/hyperactivity disorder. Broadly, Dr.Ceceli is interested in the neural signature of cognitive control in drug addiction. His work at the NARC lab focuses on the structural and functional brain substrates of cognitive and habitual control in cocaine and heroin addiction. The goals of Dr. Ceceli’s research include 1) better understanding how salient drug cues affect self-control in individuals with substance use disorders, 2) revealing common and distinct cognitive control markers across substance classes to identify precise biomarkers, and 3) improving addiction treatment outcomes via ecologically valid estimates of drug-biased processing. Dr. Ceceli is supported by a National Institute on Drug Abuse T32 Training Grant in Substance Use Disorders.

Greg Kronberg, PhD

Greg completed his PhD in Biomedical Engineering from the City College of New York, where he worked in Lucas C. Parra’s group. His graduate work in neural engineering focused on optimizing non-invasive brain stimulation technologies. He used computational models in vitro experiments to understand how weak electromagnetic fields can be used to alter synaptic plasticity. Greg joined the NARC lab as a postdoc in 2020. He is interested in using tools from engineering, machine learning, and computational neuroscience to subtype individuals with substance use disorders and help predict treatment outcomes. He is currently characterizing the dynamics of brain networks in fMRI responses to naturalistic stimuli to identify addiction and recovery related brain states.

Yuefeng Huang, PhD

Yuefeng Huang received his Ph.D. degree from the University of Texas at Dallas after completing training in the Cognition and Neuroscience program under the supervision of Dr. Sven Vanneste. His graduate work focuses on using non-invasive brain stimulation (e.g., tDCS) and neuroimaging methods (e.g., fMRI, EEG) to study human memory functions. After graduated, he joined the Neuroimaging of Addictions and Related Conditions (NARC) lab as a postdoctoral fellow in 2020. In the NARC lab, he is interested in studying the neuromechanism of addiction and aiming to identify neuromarkers for therapeutic Interventions. He will also focus on studying sex differences in addiction and how sex hormones modulate the impaired response inhibition and salience attribution (iRISA) model in addiction.

Pierre-Olivier Gaudreault, PhD

Pierre-Olivier is a postdoctoral fellow at the NARC laboratory. He completed his PhD in clinical neuropsychology at the Université de Montréal, Canada under the supervision of Dr. Julie Carrier and Dr Nadia Gosselin. His research focused on the implication of the brain anatomical connectivity, measured through diffusion MRI, in the electrophysiological characteristics of sleep spindles. The goal of Dr. Gaudreault’s current research is to better understand how brain networks are implicated in drug addiction and its recovery using multimodal techniques (e.g., EEG, diffusion MRI, transcranial Direct Current Stimulation, sleep actigraphy). In the NARC lab, he specifically focuses on the use of tDCS to modulate drug craving in cocaine-addicted individuals and the use of diffusion MRI to establish the relationship between the white matter anatomical connectivity and recovery measures in individuals with heroin use disorder. Dr. Gaudreault is also heavily involved in teaching and community outreach, having been invited to present in multiple events on sleep and health as well as to teach numerous university courses on sleep, cognition, and psychopharmacology at the undergraduate and graduate level. Dr. Gaudreault is now combining his clinical interests and research expertise to explore how brain abnormalities and disrupted sleep/wake cycle contribute to the symptomatology of addiction. he is the recipient of a Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship.

Sarah King

Sarah is a PhD student in the Neuroscience graduate program at Mount Sinai. She previously completed a post-baccalaureate under the mentorship of Dr. Carlo Pierpaoli in the Quantitative Medical Imaging Section at the NIH, where she studied the neuropathology of mild traumatic brain injury using diffusion MRI and tissue histology. Her current research in the NARC research program aims to leverage advanced neuroimaging methods to understand how drug addiction alters the connectivity of brain regions, especially the prefrontal cortex and habenula. She is also interested in understanding social factors of addiction through naturalistic speech.

Jack Gray

Jack oversees technical operations for the NARC lab. Jack obtained his degree in electrical and computer engineering, with a minor in neuroscience from Auburn University. He now manages data for the lab.

Natalie McClain

Natalie is a clinical research coordinator at the NARC lab. She graduated from Barnard College with a degree in Cellular Neuroscience and Mathematics in 2022. Before joining the NARC lab, Natalie worked in the Losonczy Lab at the Zuckerman Institute under Adrian Negrean investigating in vivo place-cell tuning and the electrophysiological mechanisms of memory retrieval. Natalie intends to pursue a doctoral degree in neuroscience with hopes of specializing in addiction. This is motivated by her desire to both advance our understanding of the addicted brain and to contribute to the development of therapeutic interventions for individuals suffering from addiction.

Maggie Boros

Maggie is a researcher coordinator at the NARC lab. She is currently a senior at Fordham University in the Integrative Neuroscience program, where she will graduate in May of 2023 with a BS in neuroscience and philosophy. In addition to the NARC lab, Maggie is also part of the Memory and Aging Lab at Fordham University under Dr. Karen Siedlecki where she primarily studies the involvance of COVID-19 infection and ACE2 receptors in olfactory neuroepithelium. She is also a part of the Engaged Leaders research Fellowship through Fordham's Center for Community Engaged Learning, where she studies literacy rates of students at Title I schools in the Bronx to understand the cognitive impact of systemic disparities in public education. Prior to being a researcher at the NARC lab, Maggie was a volunteer researcher at the Joyner Lab at Memorial Sloan Kettering where she looked at the impact of Sonic hedgehog protein on the cerebellar development of mice. Maggie looks forward to starting as a full-time clinical research coordinator at the NARC lab in June of 2023 after she graduates. 

Chloe Wong

Chloe is a clinical research coordinator at the NARC lab. She graduated from New York University in 2022 with a double major in Neuroscience and Psychology. Prior to joining the lab, Chloe worked in the Perception and Brain Dynamics Lab at NYU Langone where she worked on an fMRI study investigating the neural correlates of cross-modal conscious perception. Chloe is interested in exploring the neural mechanisms of psychiatric disorders with the ultimate goal of improving treatment efficacy through existing and novel interventions and intends to pursue a doctoral degree in clinical psychology.

Rachel Drury

Rachel joined the NARC lab as a clinical research coordinator. She graduated from Northwestern University with a double major in psychology and opera performance. Following her undergraduate studies, Rachel was a research assistant and paraeducator at the International Institute for the Brain, where her team investigated the cognitive effects of novel music therapy treatments in children with severe traumatic brain injuries. Rachel is interested in studying how the neurobiological underpinnings of substance use disorders can shape novel treatments such as mindfulness-based interventions and transcranial direct current stimulation (tDCS). She aspires to continue pursuing addiction research as a clinical psychologist.

Lucy Bao

Lucy is a volunteer at the NARC Lab. She is currently an undergraduate student at Macaulay Honors College at Hunter where she studies Biology with a focus in Behavioral Neurobiology. Prior to joining the NARC Lab, Lucy interned in the Hurd Lab at the Icahn School of Medicine under Yasmin Hurd investigating the interplay of genes and the environment to the development of addictive disorders. In the future, Lucy intends on pursuing a medical degree.

Lab Alumni

• Muhammad Parvaz - Assistant Professor of Psychiatry and Neuroscience at the Icahn School of Medicine, Principal Investigator of the Motivational and Affective Psychopathology Lab
• Anna Konova - Assistant Professor at Rutgers University, Principal Invesigator of the Addiction and Decision Neuroscience Lab
• Scott Moeller - Vice Chair for Research, Associate Professor, and Principal Investigator at Stony Brook University
• Anna Zilverstand - Assistant Professor and Principal Investigator at the University of Minnesota
• Rachel Rabin - Assistant Professor and Principal Investigator at McGill University 
• Anna Huang – Assistant Professor at Vanderbilt University
• Sivan Kinreich – Research Scientist at SUNY Downstate Medical Center, Department of Psychiatry
• Keren Bachi - Assistant Professor at the Icahn School of Medicine, Principal Investigator of the Psychosocial Neuroimmune Addiction Laboratory
• Gabriela Gan – Project Manager at Ludwig Boltzmann Gesellschaft, Open Innovation in Science Center

Collaborations

In addition to our core team, we collaborate with the following investigators:

• Guillermo Cecchi, PhD and Carla Agurto, PhD (IBM)
• Conor Liston, MD, PhD (Weill Cornell Medical College)
• The ENIGMA Addiction working group (University of Vermont)
• Junqian (Gordon) Xu, PhD (Baylor College of Medicine)