Faculty within the Center for Molecular Integrative Neuroresilience at the Icahn School of Medicine at Mount Sinai actively publish articles in leading journals about research findings related to their work.
2021-Present
Iban-Arias R, Sebastian-Valverde M, Wu H, Lyu W, Wu Q, Simon J, Pasinetti GM. Role of Polyphenol-Derived Phenolic Acid in Mitigation of Inflammasome-Mediated Anxiety and Depression. Biomedicines. 2022 May 28;10(6). doi: 10.3390/biomedicines10061264. PubMed PMID: 35740286; PubMed Central PMCID: PMC9219614.
Van Doren WW, Iqbal UH, Helmer DA, Litke DR, Simon JE, Wu Q, Zhao D, Yin Z, Ho L, Osinubi O, Pasinetti GM. Changes in polyphenol serum levels and cognitive performance after dietary supplementation with Concord grape juice in veterans with Gulf War Illness. Life Sci. 2022;292:119797. doi:10.1016/j.lfs.2021.119797
Lyu W, Rodriguez D, Ferruzzi MG, Pasinetti GM, Murrough JW, Simon JE, Wu Q. Chemical, Manufacturing, and Standardization Controls of Grape Polyphenol Dietary Supplements in Support of a Clinical Study: Mass Uniformity, Polyphenol Dosage, and Profiles. Front Nutr. 2021;8:780226. doi: 10.3389/fnut.2021.780226. eCollection 2021. PubMed PMID: 34977124; PubMed Central PMCID: PMC8716858.
Lyu W, Omar T, Patel H, Rodriguez D, Ferruzzi MG, Pasinetti GM, Murrough JW, Muzzio FJ, Simon JE, Wu Q.Dissolution Study on Grape Polyphenol Hard Gelatin Capsule Dietary Supplements. Front Nutr.2021;8:780260. doi: 10.3389/fnut.2021.780260. eCollection 2021. PubMed PMID: 34901128; PubMed Central PMCID: PMC8656703.
Caracci F, Harary J, Simkovic S, Pasinetti GM. Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity. J Agric Food Chem. 2020 Feb 19;68(7):1808-1815. doi: 10.1021/acs.jafc.9b01970. Epub 2019 Sep 26. PMID: 31532659.
Yang EJ, Pasinetti GM. Transient anxiety and depression-like behaviors are causally associated to depletion of Forkhead box P3 expression in regulatory T cells through inflammasome activation in the brain. Submitted for consideration to Mol. Psychiatry, 2023. Preprint DOI: https://doi.org/10.21203/rs.3.rs-2410197/v1
Osman A, Hofford RS, Meckel KR, Dave YA, Zeldin SM, Shipman AL, Lucerne KE, Trageser KJ, Oguchi T, Pasinetti GM, Kiraly, DD. Dietary polyphenols drive alterations in behavior, transcriptional regulation, and commensal microbiota in models of opioid use. Scientific Reports, 2023 BioRxiv DOI: https://doi.org/10.1101/2022.06.14.496180
Yang EJ, Frolinger T, Westfall S, Iqbal U, Murrough J, Pasinetti GM. The bioactive dietary polyphenol preparation alleviates depression and anxiety-like behaviors by modulating the regional heterogeneity of microglia morphology. Submitted to Molecular Nutrition and Food Research, 2023. (Under review). BioRxiv DOI: https://www.biorxiv.org/content/10.1101/2023.03.30.534961v1
Yang EJ*, Frolinger T*, Barak O, Iqbal U, Ayata P, Estill M, Li Shen, Trageser KJ, Pasinetti GM. The role of the Toll like receptor 4 signaling in sex mediated persistency of depression-like behavior in response to chronic stress. iScience. 2023. Preprint DOI: 10.2139/ssrn.4369790 9
Lyu W, Xie L, Pasinetti GM, Murrough JW, Marchidan M, Karpman E, Dobbs M, Ferruzzi MG, Simon JE, Wu Q. Method development with high-throughput enhanced matrix removal followed by UHPLC-QqQ-MS/MS for analysis of grape polyphenol metabolites in human urine. In preparation (2023)
Representative Publications (2018-2020)
Westfall S, Pasinetti GM. The gut microbiota links dietary polyphenols with management of psychiatric mood disorders. Frontiers in Neuroscience, 2019. DOI: 10.3389/fnins.2019.01196
Westfall S, Dinh D, Pasinetti GM. Investigation of Potential Brain Microbiome in Alzheimer’s Disease: Implications of Study Bias. Journal of Alzheimer’s Disease, 2020. DOI: 10.3233/JAD-191328.
Yamasaki TR, Ono K, Ho L, Pasinetti GM. Gut Microbiome-Modified Polyphenolic Compounds Inhibit alpha- synuclein Seeding and Spreading in alpha-synucleinopathies. Frontiers in Neurosciences, 2020. DOI: 10.3389/fnins.2020.00398
Helmer DA, Van Doren W, Litke D, Tseng C, Ho L, Osinubi O, Pasinetti GM. Safety, tolerability and efficacy of dietary supplementation with Concord grape juice in Gulf War Veterans with Gulf War Illness: a phase I/IIA, randomized, double-blind, placebo-controlled trial. International Journal of Environmental Research and Public Health, 2020. https://doi.org/10.3390/ijerph17103546
Sebastian-Valverde M, Sanchez R, Kumar K, De Vita RJ, Pasinetti GM. Characterization of novel small molecule inhibitors of the NLRP3 inflammasome. Journal Biological Chemistry, Provisionally Accepted for Publication, 2021.
Smith C, Trageser KJ, Frolinger T, Sebastian-Valverde M, Iqbal U, Zeng E, Herman FJ, Pasinetti GM. Anxioloytic Effects of NLRP3 Inflammasome Inhibition in a Model of Chronic Sleep Deprivation. Translational Psychiatry, 2020. DOI: 10.1038/s41398-020-01189-3.
Westfall S, Carracci F, Estill M, Zhao D, Wu Q, Shen L, Simon J, Pasinetti GM. Optimization of Probiotic Therapeutics using Machine Learning in an Artificial Human Gastrointestinal Tract. Nature Scientific Reports, 2020. DOI: 10.1038/s41598-020-79947-y
Westfall S, Caracci F, Zhao D, Wu Q, Frolinger T, Simon J, Pasinetti GM. Microbiota metabolites modulate the regulatory T to T helper 17 (Treg/Th17) imbalance promoting resilience to stress-induced psychological impairment. Brain Behavior and Immunity, 2020. DOI: 10.1016/j.bbi.2020.10.013.
Westfall S, Caracci F, Estill M, Frolinger T, Shen L, Pasinetti GM. Sensitization to Chronic Stress-Inuduced Depression and Anxiety Modulated by Gut-Brain-Axis Immunity. Frontiers in Immunology. Provisionally Accepted for Publication, 2021.
Trageser KJ, Sebastian M, Naughton SX, Pasinetti GM. The Innate Immune System and Inflammatory Priming: Linking Mood Disorders and Gulf War Illness. Frontiers in Psychiatry, 2020. DOI: 10.3389/fpsyt.2020.00704
Naughton SX, Raval U, Pasinetti GM. The Viral Hypothesis in Alzheimer’s Disease: Insight toward Novel Biomarkers. Journal of Personalized Medicine, 2020. DOI: 10.3390/jpm10030074.
Sebastian-Valverde M, Pasinetti GM. The NLRP3 inflammasome as a critical factor in the inflammaging process. Cells, 2020. 10.3390/cells9061552.
Docampo-Palacios M, Hernandez A, Olubu A, Gamiotea-Turro D, Valerino-Diaz A, Viegas L, Nduke I, de Fatima A, Heiss C, Azadi P, Pasinetti GM and Dixon R. Glucuronidation of Methylated Quercetin Derivatives: Chemical and Biochemical Approaches. Journal of Agricultural and Food Chemistry, 2021. DOI: 10.1021/acs.jafc.0c04500
Adiji O, Docampo-Palacios M, Alvarez-Hernandez A, Pasinetti GM, Wang X, Dixon R. UGT84F9 is the Major Flavonoid UDP-glucuronosyltransferase in Medicago truncatula. Plant Physiology, 2021. DOI: 10.1093/plphys/kiab016
Westfall, Iqbal U, Sebastian M, Pasinetti GM. Gut Microbiota Mediated Allostasis Prevents Stress-induced Neuroinflammatory Risk Factors of Alzheimer’s Disease. Prog Mol Biol Transl Sci, 2020. DOI: 10.1016/bs.pmbts.2019.06.013.
Decampo-Palacios M, Alvarez-Hernandez A, de Fatima A, Pasinetti GM and Dixon R. Efficient Chemical Synthesis of (Epi)Catechin Glucuronides as Brain-Targeted Metabolites for Treatment of Alzheimer’s and Other Neurological Diseases. ACS Omega, 2020. DOI: 10.1021/acsomega.0c04512
Ho L, Zhao D, Mogno I, Ono K, Tsuji M, Carry E, Brathwaite J, Pasinetti GM. Heterogeneity in gut microbiota drives polyphenol metabolism that influences alpha-synuclein misfolding and toxicity. J. Nutritional Biochemistry DOI: 10.1016/j.jnutbio.2018.10.019 (2019).
Wang J, Hodes G, Zhang H, Zhang S, Zhao W, Golden S, Bi W, Menard C, Kana V, Leboef M, Tiano S, Esteban-Fernandez A, Xie M, Bregman D, Ho L, Dixon R, Merad M, Han MH, Russo S, Pasinetti GM. Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nature Communications DOI:10.1038/s41467-017-02794-5 (2018).
Wang J, Zhao D, Tiano S, Esteban A, Yuan N, Smith C, Brathwaite J, Jlayer Z, Wu Q, Simon J, Trageser KJ Pasinetti GM. Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of stress. Translational Psychiatry. DOI: 10.1038/s41398-020-0859-x
Wang J, Blaze J, Haghighi F, Kim-Schulze K, Trageser KJ, Pasinetti GM. Characterization of 3(3,4-dihydroxy-phenyl) propionic acid as a novel microbiome-derived epigenetic modifier in attenuation of immune Inflammatory response in human monocytes. Molecular Immunology. DOI: 10.1016/j.molimm.2020.07.003
Menard, C., Pfau, M.L., Hodes, G.E. et al. Social stress induces neurovascular pathology promoting depression. Nat Neurosci 20, 1752–1760 (2017). DOI: 10.1038/s41593-017-0010-3.
Pfau ML, Menard C, Russo SJ. Inflammatory Mediators in Mood Disorders: Therapeutic Opportunitie. Annual Review of Pharmacology and Toxicology, 2018. DOI: 10.1146/annurev-pharmtox-010617-052823.
Cathomas F, Murrough JW, Nestler EJ, Han MH, Russo SJ. Neurobiology of resilience: interface between mind and body. Biological Psychiatry, 2019. DOI: 10.1016/j.biopsych.2019.04.011
Chan KL, Cathomas F, Russo SJ. Central and peripheral inflammation link metabolic syndrome and major depressive disorder. Physiology, 2019. DOI: 10.1152/physiol.00047.2018
Nasca C, Menard C…Russo SJ. Multidimensional predictors of susceptibility and resilience to social defeat stress. Biological Psychiatry, 2019. DOI: 10.1016/j.biopsych.2019.06.030
Yamamuro, K., Bicks, L.K., Leventhal, M.B. et al. A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice. Nat Neurosci 23, 1240–1252 (2020). https://doi.org/10.1038/s41593-020-0695-6.
Heshmati M, Christoffel DJ… Russo SJ. Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens. Neurobiology of Disease, 2020. DOI: 10.1523/JNEUROSCI.2568-19.2020.
Murrough JW, Russo SJ. The neurobiology of resilience: complexity and hope. Biological Psychiatry, 2019. DOI: 10.1016/j.biopsych.2019.07.016
Guevara CA, Matikainen-Ankey BA…. Russo SJ. LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress. Journal of Neurophysiology, 2020. DOI: 10.1152/jn.00137.2020.