NanoCore, a Core Facility of the Icahn Genomics Institute (IGI), provides a variety of services and products to assist researchers in pursuing their investigations. They are available to researchers both within and outside of the Icahn School of Medicine at Mount Sinai.
Services
We have advanced facilities and expert staff to ensure reliable production, characterization, and quality control of mRNA and lipid nanoparticle (LNP)-mRNA formulations. Our core is equipped with state-of-the-art technology to produce high-quality mRNA and LNP-mRNA formulations.
Our meticulous approach includes comprehensive optimization of sequences and structural elements, such as untranslated regions, to boost mRNA stability and translational efficiency. We employ purification technologies to eliminate residual components and byproducts, ensuring the production of high-quality IVT mRNA transcripts and LNP-mRNA formulations.
We are spearheading the development of new ionizable lipids and LNP-mRNA formulations, establishing platforms for mRNA synthesis, purification, and quality control. Our commitment to innovation is reflected in our ongoing efforts to bring the latest technologies to Mount Sinai and develop new formulations for a range of medical fields including cancer, infectious disease, and genetic disorders as well as cardiovascular disease.
Products
Reporter mRNA
We provide reporter mRNA for tracking delivery efficiency and/or duration of expression in vitro and in vivo. Our IVT mRNA resembles fully mature mRNA with 5’ cap, UTR, and 3’ polyA.
- eGFP mRNA
- mCherry mRNA
- Luciferase mRNA
- Cre mRNA
We can manufacture our catalog mRNA with modified nucleotides, such as N1-methylpseudouridine, or capping technologies such as CleanCap® M6 analog, within 2-3 weeks. Please inquire for information.
LNP/mRNA formulation
We provide LNP/mRNA formulations with different chemical compositions optimized for specific applications and tissues of interest.
- SM-102 LNP
- ALC-0315 LNP
- GenVoy LNP
We also provide customized LNP with other ionizable lipids and/or mRNA for specific application.
Please contact Dr. Angelo Amabile at angelo.amabile@mssm.edu for additional product information.