Research Laboratories

Protein-nucleic acid interactions in DNA and RNA metabolism

Exploring post-transcriptional regulation of bacterial gene expression

Investigating genetic and environmental factors in neuropsychiatric disease etiology and corresponding synaptopathies.

Focusing on neuropeptides, opiate receptor signal transduction and narcotic addiction

Small molecule drug discovery, chemical biology, and target validation

Computer-aided structural biology and drug discovery

Mechanism of epigenetic alterations in cardiopulmonary vascular disease, calcium handling proteins, and small molecules inhibitors and target gene therapies.

Systems biology and systems pharmacology, cell signaling networks with emphasis on GPCR pathways

Medicinal chemistry and drug discovery: creating selective inhibitors of histone methyltransferases, biased ligands of GPCRs, and novel degraders targeting oncogenic proteins

Cellular mechanisms of nutrient signaling in intracellular glycosyation and authophagy with chemistry, crystallography and mass spectrometry methods

Computational systems biology, bioinformatics, data mining, data science, data integration, and software development for biomedical and biological research

Focusing on connective tissue pathophysiology and genetic control of morphogenesis

The role of cell cycle and apoptotic genes in cancer progression and as target for the development of novel anticancer drugs

Structural bioinformatics and structure-based drug design membrane transporters

Mass spectrometry-based proteomics, protein design, antibody therapeutics and translational sciences

Mathematical modeling and quantitative investigation of cardiac physiology, and mechanisms of initiation of arrhythmias and heart failure

Structural studies and drug discovery of serotonin receptors and transporters

Mechanisms that regulate chromatin structure and gene transcription

Structure and function of membrane transport proteins that play central roles in physiology and disease.

Translational studies on new drugs for osteoporosis, obesity and neurodegenerative diseases using cutting-edge technologies.

Structural mechanisms of epigenetic regulation of gene transcription in biology and human diseases, and structure-based drug discovery